YWHAB belongs to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants differing in the 5' UTR, but encoding the same protein, have been identified for the gene. Both variants encode the same protein, however, they are differentially expressed in hematopoietic cells.

Target	14-3-3 Protein Beta/Alpha (YWHAB)
Clonality	Polyclonal
Reactivity	Human
Tested Applications	ELISA, WB, IHC
Host	Rabbit
Recommended dilutions	WB: 1/1000, IHC-P: 1/50 - 1/100. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user.
Conjugation	Unconjugated
Immunogen	KLH-conjugated synthetic peptide between 56-85 amino acids from the N-terminal region of human YWHAB.
Isotype	IgG
Form	Liquid
Purification	Purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Storage	Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
UniProt Primary AC	P31946 (UniProt, ExPASy)
UniProt Secondary AC	A8K9K2, E1P616
UniProt Entry Name	1433B_HUMAN
NCBI Accession	NP_003395.1 NP_647539.1
KEGG	hsa:7529
String	9606.ENSP00000361930
Molecular Weight	Calculated MW: 28.1 kDa
Buffer	PBS containing 0.09% sodium azide.
Specificity	Predicted to react with Mouse, Rat, Cow and Monkey YWHAB.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.

Research Articles on 14-3-3 Protein Beta/Alpha (YWHAB)